Hello, I’m

Weipeng Mo.

Computational biologist & bioinformatics researcher

I build computational approaches to understand gene regulation across molecules, cells, and tissues.

Current appointment
The First Affiliated Hospital, Sun Yat-sen University
Research base
Guangzhou, China
Portrait of Weipeng Mo

Researching biology through data, methods, and open tools.

Across molecules, cells, and tissues.

My research sits at the intersection of genomics, computation, and tool-building. I work with long-read, single-cell, and spatial omics to reveal how gene regulation changes across biological systems—and I turn the methods behind that work into clear, reusable software.

Current focus

Cancer transcriptomics, spatial biology, and agent-ready research workflows.

Methods

Python, R, Snakemake, single-cell and spatial analysis

Open science

Reusable workflows, clear documentation, and research software

Research interests

My work combines biological questions with rigorous computational analysis and reproducible systems.

01

Single-cell & Spatial Omics

Resolving cellular states, tissue organization, and disease biology from high-dimensional molecular data.

02

Long-read Sequencing

Studying transcription, RNA processing, and epigenetic regulation at single-molecule resolution.

03

Research Systems

Building reproducible analysis tools and workflows that stay legible to both scientists and AI agents.

#Transcriptomics#Epigenetics#Nanopore sequencing#Single-cell omics#Spatial biology#3D Genome

Academic training

A foundation spanning agriculture, molecular biology, and computational genomics.

  1. 2019 — 2023

    Ph.D. in Biology

    Southern University of Science and Technology

    Research in transcriptomics, epigenetics, and single-molecule sequencing.

    Shenzhen, China

  2. 2017 — 2019

    M.S. in Agriculture

    China Agricultural University

    Graduate training in agricultural and computational life sciences.

    Beijing, China

  3. 2013 — 2017

    B.S. in Agriculture

    South China Agricultural University

    Undergraduate study in agriculture and the biological sciences.

    Guangzhou, China

Publications

Research spanning cancer biology, long-read transcriptomics, and functional genomics.

Full publication profile
  1. 01

    Engineered enhancers: Using tumor switches for precision therapy

    Weipeng Mo, Wange Lu & Nu Zhang

    Cancer Cell · 2026

    DOI ↗
  2. 02

    Systematic decoding of functional enhancer connectomes and risk variants in human glioma

    Jinfang Bi, Weipeng Mo, Man Liu, Yingjie Song, Qian Xiao, Sibo Fan, Wenbin Wang, Tengfei Shi, Yaoqiang Zheng, Jie Lian, Rong Liu, Bohan Chen, Xiaofeng Huang, Peng Li, Zhongfang Zhao, Jiandang Shi, Lei Zhang, Guangsong Su, Nu Zhang & Wange Lu

    Nature Cell Biology · 2025

    DOI ↗
  3. 03

    Single-molecule targeted accessibility and methylation sequencing of centromeres, telomeres and rDNAs in Arabidopsis

    Weipeng Mo, Yi Shu, Bo Liu, Yanping Long, Tong Li, Xiaofeng Cao, Xian Deng & Jixian Zhai

    Nature Plants · 2023

    DOI ↗
  4. 04

    An atlas of plant full-length RNA reveals tissue-specific and monocots–dicots conserved regulation of poly(A) tail length

    Jinbu Jia, Wenqin Lu, Bo Liu, Huihui Fang, Yiming Yu, Weipeng Mo, Hong Zhang, Xianhao Jin, Yi Shu, Yanping Long, Yanxi Pei & Jixian Zhai

    Nature Plants · 2022

    DOI ↗
  5. 05

    Landscape of transcription termination in Arabidopsis revealed by single-molecule nascent RNA sequencing

    Weipeng Mo, Bo Liu, Hong Zhang, Xianhao Jin, Dongdong Lu, Yiming Yu, Yuelin Liu, Jinbu Jia, Yanping Long, Xian Deng, Xiaofeng Cao, Hongwei Guo & Jixian Zhai

    Genome Biology · 2021

    DOI ↗
  6. 06

    FLEP-seq: simultaneous detection of RNA polymerase II position, splicing status, polyadenylation site and poly(A) tail length

    Yanping Long, Jinbu Jia, Weipeng Mo, Xianhao Jin & Jixian Zhai

    Nature Protocols · 2021

    DOI ↗