| Signature | Genes |
|---|---|
| Mouse ARID1A-IFN Signature | Apol9A, C1Ra, Cmpk2, Cxcl10, Ddx58, Ddx60, Dhx58, Dtx3L, Gbp2, Gbp3, Gbp7, H2-Q4, Helz2, Ifi27, Ifi35, Ifi44, Ifih1, Ifit1, Ifit3, Igtp, Iigp1, Irf7, Irf9, Irgm1, Irgm2, Isg15, Lgals3Bp, Mx2, Nmi, Oas1A, Oas1B, Oas1C, Oas2, Oasl2, Parp10, Parp12, Parp14, Parp9, Psmb8, Psmb9, Rsad2, Rtp4, Samd9L, Stat1, Stat2, Tap1, Tlr3, Tor3A, Trim12C, Trim21, Trim25, Trim30A, Uba7, Ube2L6, Usp18, Xaf1, Zbp1 |
| Human orthologs of ARID1A-IFN | CMPK2, CXCL10, DDX60, DHX58, GBP1, GBP2, GBP4, GBP7, HLA-A, HLA-B, HLA-C, HLA-E, HELZ2, IFI27, IFI27L1, IFI27L2, IFI35, IFI44, IFIH1, IFIT1, IFIT1B, IFIT3, IRF7, IRF9, IRGM, ISG15, MX1, MX2, NMI, OAS2, OASL2P, PARP10, PARP12, PARP14, PARP9, PSMB8, PSMB9, RSAD2, RTP4, STAT1, STAT2, TAP1, TLR3, TRIM21, TRIM25, UBA7, USP18, USP41, XAF1, ZBP1 |
| CD8+ T cell ISG Score | Psme1, Psmb8, Psme2, Isg15, Rtp4, B2m, Bst2, Ifit3, Ly6e, Irf7, Gbp2, Isg20, Psmb9, Psmb10, Xaf1, Socs1, Xcl1, Psma2, Stat1, Zbp1, Ptpn6, Klrk1, Irf8, Psmb2, Psma3, Lap3, Csf1, Cd47, Ccrl2, Nfkbia |
| CD8+ T cell Anti-PD1 Response | Cd2, Ctsw, Gzmd, Gzmf, H2-T23, Hspa8, Id2, Itm2b, Lsp1, Ms4a4b, Serinc3, Serpine2, Shisa5, Ly6c2, Ifi47 |
Ref1
Maxwell M B, Hom-Tedla M S, Yi J, et al. ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity. Cell, 2024. ↩︎