| Signature | Genes |
|---|---|
| E2F_TARGETS | AK2, ANP32E, ASF1A, ASF1B, ATAD2, AURKA, AURKB, BARD1, BIRC5, BRCA1, BRCA2, BRMS1L, BUB1B, CBX5, CCNB2, CCNE1, CCP110, CDC20, CDC25A, CDC25B, CDCA3, CDCA8, CDK1, CDK4, CDKN1A, CDKN1B, CDKN2A, CDKN2C, CDKN3, CENPE, CENPM, CHEK1, CHEK2, CIT, CKS1B, CKS2, CNOT9, CSE1L, CTCF, CTPS1, DCK, DCLRE1B, DCTPP1, DDX39A, DEK, DEPDC1, DIAPH3, DLGAP5, DNMT1, DONSON, DSCC1, DUT, E2F8, EED, EIF2S1, ESPL1, EXOSC8, EZH2, GINS1, GINS3, GINS4, GSPT1, H2AX, H2AZ1, HELLS, HMGA1, HMGB2, HMGB3, HMMR, HNRNPD, HUS1, ILF3, ING3, IPO7, JPT1, KIF18B, KIF22, KIF2C, KIF4A, KPNA2, LBR, LIG1, LMNB1, LUC7L3, LYAR, MAD2L1, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MELK, MKI67, MLH1, MMS22L, MRE11, MSH2, MTHFD2, MXD3, MYBL2, MYC, NAA38, NAP1L1, NASP, NBN, NCAPD2, NME1, NOLC1, NOP56, NUDT21, NUP107, NUP153, NUP205, ORC2, ORC6, PA2G4, PAICS, PAN2, PCNA, PDS5B, PHF5A, PLK1, PLK4, PMS2, PNN, POLA2, POLD1, POLD2, POLD3, POLE, POLE4, POP7, PPM1D, PPP1R8, PRDX4, PRIM2, PRKDC, PRPS1, PSIP1, PSMC3IP, PTTG1, RACGAP1, RAD1, RAD21, RAD50, RAD51AP1, RAD51C, RAN, RANBP1, RBBP7, RFC1, RFC2, RFC3, RNASEH2A, RPA1, RPA2, RPA3, RRM2, SHMT1, SLBP, SMC1A, SMC3, SMC4, SMC6, SNRPB, SPAG5, SPC24, SPC25, SRSF1, SRSF2, SSRP1, STAG1, STMN1, SUV39H1, SYNCRIP, TACC3, TBRG4, TCF19, TFRC, TIMELESS, TIPIN, TK1, TMPO, TOP2A, TP53, TRA2B, TRIP13, TUBB, TUBG1, UBE2S, UBE2T, UBR7, UNG, USP1, WDR90, WEE1, XPO1, XRCC6, ZW10 |
| EPITHELIAL_MESENCHYMAL_TRANSITION | ABI3BP, ACTA2, ADAM12, ANPEP, APLP1, AREG, BASP1, BDNF, BGN, BMP1, CADM1, CALD1, CALU, CAP2, CAPG, CCN1, CCN2, CD44, CD59, CDH11, CDH2, CDH6, COL11A1, COL12A1, COL16A1, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, COL5A3, COL6A2, COL6A3, COL7A1, COL8A2, COLGALT1, COMP, COPA, CRLF1, CTHRC1, CXCL1, CXCL12, CXCL6, CXCL8, DAB2, DCN, DKK1, DPYSL3, DST, ECM1, ECM2, EDIL3, EFEMP2, ELN, EMP3, ENO2, FAP, FAS, FBLN1, FBLN2, FBLN5, FBN1, FBN2, FERMT2, FGF2, FLNA, FMOD, FN1, FOXC2, FSTL1, FSTL3, FUCA1, FZD8, GADD45A, GADD45B, GAS1, GEM, GJA1, GLIPR1, GPC1, GPX7, GREM1, HTRA1, ID2, IGFBP2, IGFBP3, IGFBP4, IL15, IL32, IL6, INHBA, ITGA2, ITGA5, ITGAV, ITGB1, ITGB3, ITGB5, JUN, LAMA1, LAMA2, LAMA3, LAMC1, LAMC2, LGALS1, LOX, LOXL1, LOXL2, LRP1, LRRC15, LUM, MAGEE1, MATN2, MATN3, MCM7, MEST, MFAP5, MGP, MMP1, MMP14, MMP2, MMP3, MSX1, MXRA5, MYL9, MYLK, NID2, NNMT, NOTCH2, NT5E, NTM, OXTR, P3H1, PCOLCE, PCOLCE2, PDGFRB, PDLIM4, PFN2, PLAUR, PLOD1, PLOD2, PLOD3, PMEPA1, PMP22, POSTN, PPIB, PRRX1, PRSS2, PTHLH, PTX3, PVR, QSOX1, RGS4, RHOB, SAT1, SCG2, SDC1, SDC4, SERPINE1, SERPINE2, SERPINH1, SFRP1, SFRP4, SGCB, SGCD, SGCG, SLC6A8, SLIT2, SLIT3, SNAI2, SNTB1, SPARC, SPOCK1, SPP1, TAGLN, TFPI2, TGFB1, TGFBI, TGFBR3, TGM2, THBS1, THBS2, THY1, TIMP1, TIMP3, TNC, TNFAIP3, TNFRSF11B, TNFRSF12A, TPM1, TPM2, TPM4, VCAM1, VCAN, VEGFA, VEGFC, VIM, WIPF1, WNT5A |
| ESTROGEN_RESPONSE_EARLY | ABAT, ABCA3, ABHD2, ABLIM1, ADCY1, ADCY9, ADD3, AFF1, AKAP1, ALDH3B1, AMFR, ANXA9, AQP3, AR, AREG, ARL3, ASB13, B4GALT1, BAG1, BCL11B, BCL2, BHLHE40, BLVRB, CA12, CALB2, CALCR, CANT1, CBFA2T3, CCN5, CCND1, CD44, CELSR1, CELSR2, CHPT1, CISH, CLDN7, CLIC3, CXCL12, CYP26B1, DEPTOR, DHCR7, DHRS2, DHRS3, DLC1, DYNLT3, EEIG1, EGR3, ELF1, ELF3, ELOVL2, ELOVL5, ENDOD1, ESRP2, FARP1, FASN, FCMR, FDFT1, FHL2, FKBP4, FKBP5, FLNB, FOS, FOXC1, FRK, GAB2, GFRA1, GJA1, GLA, GREB1, HES1, HR, HSPB8, IGF1R, IGFBP4, IL17RB, IL6ST, INHBB, INPP5F, ISG20L2, ITPK1, JAK2, KAZN, KCNK15, KCNK5, KDM4B, KLF10, KLF4, KLK10, KRT13, KRT15, KRT18, KRT19, KRT8, LAD1, LRIG1, MAPT, MAST4, MED13L, MED24, MICB, MINDY1, MLPH, MPPED2, MREG, MSMB, MUC1, MYB, MYBBP1A, MYBL1, MYC, MYOF, NADSYN1, NAV2, NBL1, NCOR2, NHERF1, NPY1R, NRIP1, NXT1, OLFM1, OLFML3, OPN3, OVOL2, P2RY2, PAPSS2, PDLIM3, PDZK1, PEX11A, PGR, PLAAT3, PMAIP1, PODXL, PPIF, PRSS23, PTGES, RAB17, RAB31, RAPGEFL1, RARA, RASGRP1, RBBP8, REEP1, RET, RETREG1, RHOBTB3, RHOD, RPS6KA2, RRP12, SCARB1, SCNN1A, SEC14L2, SEMA3B, SFN, SH3BP5, SIAH2, SLC16A1, SLC19A2, SLC1A1, SLC1A4, SLC22A5, SLC24A3, SLC26A2, SLC27A2, SLC2A1, SLC37A1, SLC39A6, SLC7A2, SLC7A5, SNX24, SOX3, STC2, SULT2B1, SVIL, SYBU, SYNGR1, SYT12, TBC1D30, TFAP2C, TFF1, TFF3, TGIF2, TGM2, THSD4, TIAM1, TIPARP, TJP3, TMEM164, TMPRSS3, TOB1, TPBG, TPD52L1, TSKU, TTC39A, TUBB2B, UGCG, UNC119, WFS1, WWC1, XBP1, ZNF185 |
| ESTROGEN_RESPONSE_LATE | ABCA3, ABHD2, ACOX2, ADD3, AFF1, AGR2, ALDH3A2, ALDH3B1, AMFR, ANXA9, AREG, ARL3, ASCL1, ASS1, ATP2B4, BAG1, BATF, BCL2, BLVRB, BTG3, CA12, CA2, CACNA2D2, CALCR, CAV1, CCN5, CCNA1, CCND1, CD44, CD9, CDC20, CDC6, CDH1, CELSR2, CHPT1, CHST8, CISH, CKB, CLIC3, COX6C, CPE, CXCL12, CXCL14, CYP26B1, CYP4F11, DCXR, DHCR7, DHRS2, DLG5, DNAJC1, DNAJC12, DUSP2, DYNLT3, EEIG1, EGR3, ELOVL5, EMP2, ETFB, FABP5, FARP1, FDFT1, FGFR3, FKBP4, FKBP5, FLNB, FOS, FOXC1, FRK, GAL, GALE, GFUS, GINS2, GJB3, GLA, GPER1, HMGCS2, HOMER2, HPRT1, HR, HSPA4L, HSPB8, ID2, IDH2, IGFBP4, IGSF1, IL17RB, IL6ST, IMPA2, ISG20, ITPK1, JAK1, JAK2, KCNK5, KIF20A, KLF4, KLK10, KLK11, KRT13, KRT19, LAMC2, LARGE1, LLGL2, LSR, LTF, MAPK13, MAPT, MDK, MEST, METTL3, MICB, MOCS2, MYB, MYOF, NAB2, NBL1, NCOR2, NHERF1, NMU, NPY1R, NRIP1, NXT1, OLFM1, OPN3, OVOL2, PAPSS2, PCP4, PDCD4, PDLIM3, PDZK1, PERP, PGR, PKP3, PLAAT3, PLAC1, PLK4, PLXNB1, PPIF, PRKAR2B, PRLR, PRSS23, PTGER3, PTGES, PTPN6, RAB31, RABEP1, RAPGEFL1, RBBP8, RET, RNASEH2A, RPS6KA2, S100A9, SCARB1, SCNN1A, SCUBE2, SEMA3B, SERPINA1, SERPINA3, SERPINA5, SFN, SGK1, SIAH2, SLC16A1, SLC1A4, SLC22A5, SLC24A3, SLC26A2, SLC27A2, SLC29A1, SLC2A8, SLC7A5, SNX10, SORD, SOX3, ST14, ST6GALNAC2, STIL, SULT2B1, TFAP2C, TFF1, TFF3, TFPI2, TH, TIAM1, TJP3, TMPRSS3, TNNC1, TOB1, TOP2A, TPBG, TPD52L1, TPSAB1, TRIM29, TSPAN13, TST, UGDH, UNC13B, WFS1, XBP1, XRCC3, ZFP36 |
| FATTY_ACID_METABOLISM | AADAT, ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADVL, ACAT2, ACO2, ACOT2, ACOT8, ACOX1, ACSL1, ACSL4, ACSL5, ACSM3, ACSS1, ADH1C, ADH7, ADIPOR2, ADSL, ALAD, ALDH1A1, ALDH3A1, ALDH3A2, ALDH9A1, ALDOA, AOC3, APEX1, AQP7, AUH, BCKDHB, BLVRA, BMPR1B, BPHL, CA2, CA4, CA6, CBR1, CBR3, CD1D, CD36, CEL, CIDEA, CPOX, CPT1A, CPT2, CRAT, CRYZ, CYP1A1, CYP4A11, CYP4A22, D2HGDH, DECR1, DHCR24, DLD, DLST, ECH1, ECHS1, ECI1, ECI2, EHHADH, ELOVL5, ENO2, ENO3, EPHX1, ERP29, ETFDH, FABP1, FABP2, FASN, FH, FMO1, G0S2, GABARAPL1, GAD2, GAPDHS, GCDH, GLUL, GPD1, GPD2, GRHPR, GSTZ1, H2AZ1, HADH, HADHB, HAO2, HCCS, HIBCH, HMGCL, HMGCS1, HMGCS2, HPGD, HSD17B10, HSD17B11, HSD17B4, HSD17B7, HSDL2, HSP90AA1, HSPH1, IDH1, IDH3B, IDH3G, IDI1, IL4I1, INMT, KMT5A, LDHA, LGALS1, LTC4S, MAOA, MCEE, MDH1, MDH2, ME1, METAP1, MGLL, MIF, MIX23, MLYCD, NBN, NCAPH2, NSDHL, NTHL1, ODC1, OSTC, PCBD1, PDHA1, PDHB, PPARA, PRDX6, PSME1, PTPRG, PTS, RAP1GDS1, RDH11, RDH16, REEP6, RETSAT, S100A10, SDHA, SDHC, SDHD, SERINC1, SLC22A5, SMS, SUCLA2, SUCLG1, SUCLG2, TDO2, TP53INP2, UBE2L6, UGDH, UROD, UROS, VNN1, XIST, YWHAH |
| G2M_CHECKPOINT | ABL1, AMD1, ARID4A, ATF5, ATRX, AURKA, AURKB, BARD1, BCL3, BIRC5, BRCA2, BUB1, BUB3, CASP8AP2, CBX1, CCNA2, CCNB2, CCND1, CCNF, CCNT1, CDC20, CDC25A, CDC25B, CDC27, CDC45, CDC6, CDC7, CDK1, CDK4, CDKN1B, CDKN2C, CDKN3, CENPA, CENPE, CENPF, CHAF1A, CHEK1, CHMP1A, CKS1B, CKS2, CTCF, CUL1, CUL3, CUL4A, CUL5, DBF4, DDX39A, DKC1, DMD, DR1, DTYMK, E2F1, E2F2, E2F3, E2F4, EFNA5, EGF, ESPL1, EWSR1, EXO1, EZH2, FANCC, FBXO5, FOXN3, G3BP1, GINS2, GSPT1, H2AX, H2AZ1, H2AZ2, H2BC12, HIF1A, HIRA, HMGA1, HMGB3, HMGN2, HMMR, HNRNPD, HNRNPU, HOXC10, HSPA8, HUS1, ILF3, INCENP, JPT1, KATNA1, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIF5B, KMT5A, KNL1, KPNA2, KPNB1, LBR, LIG3, LMNB1, MAD2L1, MAP3K20, MAPK14, MARCKS, MCM2, MCM3, MCM5, MCM6, MEIS1, MEIS2, MKI67, MNAT1, MT2A, MTF2, MYBL2, MYC, NASP, NCL, NDC80, NEK2, NOLC1, NOTCH2, NSD2, NUMA1, NUP50, NUP98, NUSAP1, ODC1, ODF2, ORC5, ORC6, PAFAH1B1, PBK, PDS5B, PLK1, PLK4, PML, POLA2, POLE, POLQ, PRC1, PRIM2, PRMT5, PRPF4B, PTTG1, PTTG3P, PURA, RACGAP1, RAD21, RAD23B, RAD54L, RASAL2, RBL1, RBM14, RPA2, RPS6KA5, SAP30, SFPQ, SLC12A2, SLC38A1, SLC7A1, SLC7A5, SMAD3, SMARCC1, SMC1A, SMC2, SMC4, SNRPD1, SQLE, SRSF1, SRSF10, SRSF2, SS18, STAG1, STIL, STMN1, SUV39H1, SYNCRIP, TACC3, TENT4A, TFDP1, TGFB1, TLE3, TMPO, TNPO2, TOP1, TOP2A, TPX2, TRA2B, TRAIP, TROAP, TTK, UBE2C, UBE2S, UCK2, UPF1, WRN, XPO1, YTHDC1 |
| GLYCOLYSIS | ABCB6, ADORA2B, AGL, AGRN, AK3, AK4, AKR1A1, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALG1, ANG, ANGPTL4, ANKZF1, ARPP19, ARTN, AURKA, B3GALT6, B3GAT1, B3GAT3, B3GNT3, B4GALT1, B4GALT2, B4GALT4, B4GALT7, BIK, BPNT1, CACNA1H, CAPN5, CASP6, CD44, CDK1, CENPA, CHPF, CHPF2, CHST1, CHST12, CHST2, CHST4, CHST6, CITED2, CLDN3, CLDN9, CLN6, COG2, COL5A1, COPB2, CTH, CXCR4, CYB5A, DCN, DDIT4, DEPDC1, DLD, DPYSL4, DSC2, ECD, EFNA3, EGFR, EGLN3, ELF3, ENO1, ENO2, ERO1A, EXT1, EXT2, FAM162A, FBP2, FKBP4, FUT8, G6PD, GAL3ST1, GALE, GALK1, GALK2, GAPDHS, GCLC, GFPT1, GFUS, GLCE, GLRX, GMPPA, GMPPB, GNE, GNPDA1, GOT1, GOT2, GPC1, GPC3, GPC4, GPR87, GUSB, GYS1, GYS2, HAX1, HDLBP, HK2, HMMR, HOMER1, HS2ST1, HS6ST2, HSPA5, IDH1, IDUA, IER3, IGFBP3, IL13RA1, IRS2, ISG20, KDELR3, KIF20A, KIF2A, LCT, LDHA, LDHC, LHPP, LHX9, MDH1, MDH2, ME1, ME2, MED24, MERTK, MET, MIF, MIOX, MPI, MXI1, NANP, NASP, NDST3, NDUFV3, NOL3, NSDHL, NT5E, P4HA1, P4HA2, PAM, PAXIP1, PC, PDK3, PFKFB1, PFKP, PGAM1, PGAM2, PGK1, PGLS, PGM2, PHKA2, PKM, PKP2, PLOD1, PLOD2, PMM2, POLR3K, PPFIA4, PPIA, PPP2CB, PRPS1, PSMC4, PYGB, PYGL, QSOX1, RARS1, RBCK1, RPE, RRAGD, SAP30, SDC1, SDC2, SDC3, SDHC, SLC16A3, SLC25A10, SLC25A13, SLC35A3, SLC37A4, SOD1, SOX9, SPAG4, SRD5A3, STC1, STC2, STMN1, TALDO1, TFF3, TGFA, TGFBI, TKTL1, TPBG, TPI1, TPST1, TXN, UGP2, VCAN, VEGFA, VLDLR, XYLT2, ZNF292 |
| HEDGEHOG_SIGNALING | ACHE, ADGRG1, AMOT, CDK5R1, CDK6, CELSR1, CNTFR, CRMP1, DPYSL2, ETS2, GLI1, HEY1, HEY2, L1CAM, LDB1, MYH9, NF1, NKX6-1, NRCAM, NRP1, NRP2, OPHN1, PLG, PML, PTCH1, RASA1, RTN1, SCG2, SHH, SLIT1, THY1, TLE1, TLE3, UNC5C, VEGFA, VLDLR |
| HEME_METABOLISM | ABCB6, ABCG2, ACKR1, ACP5, ACSL6, ADD1, ADD2, ADIPOR1, AGPAT4, AHSP, ALAD, ALAS2, ALDH1L1, ALDH6A1, ANK1, AQP3, ARHGEF12, ARL2BP, ASNS, ATG4A, ATP6V0A1, BACH1, BCAM, BLVRA, BLVRB, BMP2K, BNIP3L, BPGM, BSG, BTG2, BTRC, C3, CA1, CA2, CAST, CAT, CCDC28A, CCND3, CDC27, CDR2, CIR1, CLCN3, CLIC2, CPOX, CROCCP2, CTNS, CTSB, CTSE, DAAM1, DCAF10, DCAF11, DCUN1D1, DMTN, E2F2, EIF2AK1, ELL2, ENDOD1, EPB41, EPB42, EPOR, ERMAP, EZH1, FBXO34, FBXO7, FBXO9, FECH, FN3K, FOXJ2, FOXO3, FTCD, GAPVD1, GATA1, GCLC, GCLM, GDE1, GLRX5, GMPS, GYPA, GYPB, GYPC, GYPE, H1-0, H4C3, HAGH, HBB, HBBP1, HBD, HBQ1, HBZ, HDGF, HEBP1, HMBS, HTATIP2, HTRA2, ICAM4, IGSF3, ISCA1, KAT2B, KDM7A, KEL, KHNYN, KLF1, KLF3, LAMP2, LMO2, LPIN2, LRP10, MAP2K3, MARCHF2, MARCHF8, MARK3, MBOAT2, MFHAS1, MGST3, MINPP1, MKRN1, MOCOS, MOSPD1, MPP1, MXI1, MYL4, NARF, NCOA4, NEK7, NFE2, NFE2L1, NNT, NR3C1, NUDT4, OPTN, OSBP2, P4HA2, PC, PDZK1IP1, PGLS, PICALM, PIGQ, PPOX, PPP2R5B, PRDX2, PSMD9, RAD23A, RANBP10, RAP1GAP, RBM38, RBM5, RCL1, RHAG, RHCE, RHD, RIOK3, RNF123, RNF19A, SDCBP, SEC14L1, SELENBP1, SIDT2, SLC10A3, SLC11A2, SLC22A4, SLC25A37, SLC25A38, SLC2A1, SLC30A1, SLC30A10, SLC4A1, SLC66A2, SLC6A8, SLC6A9, SLC7A11, SMOX, SNCA, SPTA1, SPTB, SYNJ1, TAL1, TCEA1, TENT5C, TFDP2, TFRC, TMCC2, TMEM9B, TNRC6B, TNS1, TOP1, TRAK2, TRIM10, TRIM58, TSPAN5, TSPO2, TYR, UBAC1, UCP2, UROD, UROS, USP15, VEZF1, XK, XPO7, YPEL5 |
| HYPOXIA | ACKR3, ADM, ADORA2B, AK4, AKAP12, ALDOA, ALDOB, ALDOC, AMPD3, ANGPTL4, ANKZF1, ANXA2, ATF3, ATP7A, B3GALT6, B4GALNT2, BCAN, BCL2, BGN, BHLHE40, BNIP3L, BRS3, BTG1, CA12, CASP6, CAV1, CAVIN1, CAVIN3, CCN1, CCN2, CCN5, CCNG2, CDKN1A, CDKN1B, CDKN1C, CHST2, CHST3, CITED2, COL5A1, CP, CSRP2, CXCR4, DCN, DDIT3, DDIT4, DPYSL4, DTNA, DUSP1, EDN2, EFNA1, EFNA3, EGFR, ENO1, ENO2, ENO3, ERO1A, ERRFI1, ETS1, EXT1, F3, FAM162A, FBP1, FOS, FOSL2, FOXO3, GAA, GALK1, GAPDH, GAPDHS, GBE1, GCK, GCNT2, GLRX, GPC1, GPC3, GPC4, GPI, GRHPR, GYS1, HAS1, HDLBP, HEXA, HK1, HK2, HMOX1, HOXB9, HS3ST1, HSPA5, IDS, IER3, IGFBP1, IGFBP3, IL6, ILVBL, INHA, IRS2, ISG20, JMJD6, JUN, KDELR3, KDM3A, KIF5A, KLF6, KLF7, KLHL24, LALBA, LARGE1, LDHA, LDHC, LOX, LXN, MAFF, MAP3K1, MIF, MT1E, MT2A, MXI1, MYH9, NAGK, NCAN, NDRG1, NDST1, NDST2, NEDD4L, NFIL3, NOCT, NR3C1, P4HA1, P4HA2, PAM, PCK1, PDGFB, PDK1, PDK3, PFKFB3, PFKL, PFKP, PGAM2, PGF, PGK1, PGM1, PGM2, PHKG1, PIM1, PKLR, PKP1, PLAC8, PLAUR, PLIN2, PNRC1, PPARGC1A, PPFIA4, PPP1R15A, PPP1R3C, PRDX5, PRKCA, PYGM, RBPJ, RORA, RRAGD, S100A4, SAP30, SCARB1, SDC2, SDC3, SDC4, SELENBP1, SERPINE1, SIAH2, SLC25A1, SLC2A1, SLC2A3, SLC2A5, SLC37A4, SLC6A6, SRPX, STBD1, STC1, STC2, SULT2B1, TES, TGFB3, TGFBI, TGM2, TIPARP, TKTL1, TMEM45A, TNFAIP3, TPBG, TPD52, TPI1, TPST2, UGP2, VEGFA, VHL, VLDLR, WSB1, XPNPEP1, ZFP36, ZNF292 |
| IL2_STAT5_SIGNALING | ABCB1, ADAM19, AGER, AHCY, AHNAK, AHR, ALCAM, AMACR, ANXA4, APLP1, ARL4A, BATF, BATF3, BCL2, BCL2L1, BHLHE40, BMP2, BMPR2, CA2, CAPG, CAPN3, CASP3, CCND2, CCND3, CCNE1, CCR4, CD44, CD48, CD79B, CD81, CD83, CD86, CDC42SE2, CDC6, CDCP1, CDKN1C, CISH, CKAP4, COCH, COL6A1, CSF1, CSF2, CST7, CTLA4, CTSZ, CXCL10, CYFIP1, DCPS, DENND5A, DHRS3, DRC1, ECM1, EEF1AKMT1, EMP1, ENO3, ENPP1, EOMES, ETFBKMT, ETV4, F2RL2, FAH, FGL2, FLT3LG, FURIN, GABARAPL1, GADD45B, GALM, GATA1, GBP4, GLIPR2, GPR65, GPR83, GPX4, GSTO1, GUCY1B1, HIPK2, HK2, HOPX, HUWE1, HYCC2, ICOS, IFITM3, IFNGR1, IGF1R, IGF2R, IKZF2, IKZF4, IL10, IL10RA, IL13, IL18R1, IL1R2, IL1RL1, IL2RA, IL2RB, IL3RA, IL4R, IRF4, IRF6, IRF8, ITGA6, ITGAE, ITGAV, ITIH5, KLF6, LCLAT1, LIF, LRIG1, LRRC8C, LTB, MAFF, MAP3K8, MAP6, MAPKAPK2, MUC1, MXD1, MYC, MYO1C, MYO1E, NCOA3, NCS1, NDRG1, NFIL3, NFKBIZ, NOP2, NRP1, NT5E, ODC1, P2RX4, P4HA1, PDCD2L, PENK, PHLDA1, PHTF2, PIM1, PLAGL1, PLEC, PLIN2, PLPP1, PLSCR1, PNP, POU2F1, PRAF2, PRKCH, PRNP, PTCH1, PTGER2, PTH1R, PTRH2, PUS1, RABGAP1L, RGS16, RHOB, RHOH, RNH1, RORA, RRAGD, S100A1, SCN9A, SELL, SELP, SERPINB6, SERPINC1, SH3BGRL2, SHE, SLC1A5, SLC29A2, SLC2A3, SLC39A8, SMPDL3A, SNX14, SNX9, SOCS1, SOCS2, SPP1, SPRED2, SPRY4, ST3GAL4, SWAP70, SYNGR2, SYT11, TGM2, TIAM1, TLR7, TNFRSF18, TNFRSF1B, TNFRSF21, TNFRSF4, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TRAF1, TTC39B, TWSG1, UCK2, UMPS, WLS, XBP1 |
| IL6_JAK_STAT3_SIGNALING | A2M, ACVR1B, ACVRL1, BAK1, CBL, CCL7, CCR1, CD14, CD36, CD38, CD44, CD9, CNTFR, CRLF2, CSF1, CSF2, CSF2RA, CSF2RB, CSF3R, CXCL1, CXCL10, CXCL11, CXCL13, CXCL3, CXCL9, DNTT, EBI3, FAS, GRB2, HAX1, HMOX1, IFNAR1, IFNGR1, IFNGR2, IL10RB, IL12RB1, IL13RA1, IL15RA, IL17RA, IL17RB, IL18R1, IL1B, IL1R1, IL1R2, IL2RA, IL2RG, IL3RA, IL4R, IL6, IL6ST, IL7, IL9R, INHBE, IRF1, IRF9, ITGA4, ITGB3, JUN, LEPR, LTB, LTBR, MAP3K8, MYD88, OSMR, PDGFC, PF4, PIK3R5, PIM1, PLA2G2A, PTPN1, PTPN11, PTPN2, REG1A, SOCS1, SOCS3, STAM2, STAT1, STAT2, STAT3, TGFB1, TLR2, TNF, TNFRSF12A, TNFRSF1A, TNFRSF1B, TNFRSF21, TYK2 |
| INFLAMMATORY_RESPONSE | ABCA1, ABI1, ACVR1B, ACVR2A, ADGRE1, ADM, ADORA2B, ADRM1, AHR, APLNR, AQP9, ATP2A2, ATP2B1, ATP2C1, AXL, BDKRB1, BEST1, BST2, BTG2, C3AR1, C5AR1, CALCRL, CCL17, CCL2, CCL20, CCL22, CCL24, CCL5, CCL7, CCR7, CCRL2, CD14, CD40, CD48, CD55, CD69, CD70, CD82, CDKN1A, CHST2, CLEC5A, CMKLR1, CSF1, CSF3, CSF3R, CX3CL1, CXCL10, CXCL11, CXCL6, CXCL8, CXCL9, CXCR6, CYBB, DCBLD2, EBI3, EDN1, EIF2AK2, EMP3, EREG, F3, FFAR2, FPR1, FZD5, GABBR1, GCH1, GNA15, GNAI3, GP1BA, GPC3, GPR132, GPR183, HAS2, HBEGF, HIF1A, HPN, HRH1, ICAM1, ICAM4, ICOSLG, IFITM1, IFNAR1, IFNGR2, IL10, IL10RA, IL12B, IL15, IL15RA, IL18, IL18R1, IL18RAP, IL1A, IL1B, IL1R1, IL2RB, IL4R, IL6, IL7R, INHBA, IRAK2, IRF1, IRF7, ITGA5, ITGB3, ITGB8, KCNA3, KCNJ2, KCNMB2, KIF1B, KLF6, LAMP3, LCK, LCP2, LDLR, LIF, LPAR1, LTA, LY6E, LYN, MARCO, MEFV, MEP1A, MET, MMP14, MSR1, MXD1, MYC, NAMPT, NDP, NFKB1, NFKBIA, NLRP3, NMI, NMUR1, NOD2, NPFFR2, OLR1, OPRK1, OSM, OSMR, P2RX4, P2RX7, P2RY2, PCDH7, PDE4B, PDPN, PIK3R5, PLAUR, PROK2, PSEN1, PTAFR, PTGER2, PTGER4, PTGIR, PTPRE, PVR, RAF1, RASGRP1, RELA, RGS1, RGS16, RHOG, RIPK2, RNF144B, ROS1, RTP4, SCARF1, SCN1B, SELE, SELENOS, SELL, SEMA4D, SERPINE1, SGMS2, SLAMF1, SLC11A2, SLC1A2, SLC28A2, SLC31A1, SLC31A2, SLC4A4, SLC7A1, SLC7A2, SPHK1, SRI, STAB1, TACR1, TACR3, TAPBP, TIMP1, TLR1, TLR2, TLR3, TNFAIP6, TNFRSF1B, TNFRSF9, TNFSF10, TNFSF15, TNFSF9, TPBG, VIP |
| INTERFERON_ALPHA_RESPONSE | ADAR, B2M, BATF2, BST2, C1S, CASP1, CASP8, CCRL2, CD47, CD74, CMPK2, CMTR1, CNP, CSF1, CXCL10, CXCL11, DDX60, DHX58, EIF2AK2, ELF1, EPSTI1, GBP2, GBP4, GMPR, HELZ2, HERC6, HLA-C, IFI27, IFI30, IFI35, IFI44, IFI44L, IFIH1, IFIT2, IFIT3, IFITM1, IFITM2, IFITM3, IL15, IL4R, IL7, IRF1, IRF2, IRF7, IRF9, ISG15, ISG20, LAMP3, LAP3, LGALS3BP, LPAR6, LY6E, MOV10, MVB12A, MX1, NCOA7, NMI, NUB1, OAS1, OASL, OGFR, PARP12, PARP14, PARP9, PLSCR1, PNPT1, PROCR, PSMA3, PSMB8, PSMB9, PSME1, PSME2, RIPK2, RNF31, RSAD2, RTP4, SAMD9, SAMD9L, SELL, SLC25A28, SP110, STAT2, TAP1, TDRD7, TENT5A, TMEM140, TRAFD1, TRIM14, TRIM21, TRIM25, TRIM26, TRIM5, TXNIP, UBA7, UBE2L6, USP18, WARS1 |
| INTERFERON_GAMMA_RESPONSE | ADAR, APOL6, ARID5B, ARL4A, AUTS2, B2M, BANK1, BATF2, BPGM, BST2, BTG1, C1R, C1S, CASP1, CASP3, CASP4, CASP7, CASP8, CCL2, CCL5, CCL7, CD274, CD38, CD40, CD69, CD74, CD86, CDKN1A, CFB, CFH, CIITA, CMKLR1, CMPK2, CMTR1, CSF2RB, CXCL10, CXCL11, CXCL9, DDX60, DHX58, EIF2AK2, EIF4E3, EPSTI1, FAS, FCGR1A, FGL2, FPR1, GBP4, GBP6, GCH1, GPR18, GZMA, HELZ2, HERC6, HIF1A, HLA-A, HLA-B, HLA-DMA, HLA-DQA1, HLA-DRB1, HLA-G, ICAM1, IDO1, IFI27, IFI30, IFI35, IFI44, IFI44L, IFIH1, IFIT1, IFIT2, IFIT3, IFITM2, IFITM3, IFNAR2, IL10RA, IL15, IL15RA, IL18BP, IL2RB, IL4R, IL6, IL7, IRF1, IRF2, IRF4, IRF5, IRF7, IRF8, IRF9, ISG15, ISG20, ISOC1, ITGB7, JAK2, KLRK1, LAP3, LATS2, LCP2, LGALS3BP, LY6E, LYSMD2, MARCHF1, METTL7B, MT2A, MTHFD2, MVP, MX1, MX2, MYD88, NAMPT, NCOA3, NFKB1, NFKBIA, NLRC5, NMI, NOD1, NUP93, OAS2, OAS3, OASL, OGFR, P2RY14, PARP12, PARP14, PDE4B, PELI1, PFKP, PIM1, PLA2G4A, PLSCR1, PML, PNP, PNPT1, PSMA2, PSMA3, PSMB10, PSMB2, PSMB8, PSMB9, PSME1, PSME2, PTGS2, PTPN1, PTPN2, PTPN6, RAPGEF6, RBCK1, RIGI, RIPK1, RIPK2, RNF213, RNF31, RSAD2, RTP4, SAMD9L, SAMHD1, SECTM1, SELP, SERPING1, SLAMF7, SLC25A28, SOCS1, SOCS3, SOD2, SP110, SPPL2A, SRI, SSPN, ST3GAL5, ST8SIA4, STAT1, STAT2, STAT3, STAT4, TAP1, TAPBP, TDRD7, TNFAIP2, TNFAIP3, TNFAIP6, TNFSF10, TOR1B, TRAFD1, TRIM14, TRIM21, TRIM25, TRIM26, TXNIP, UBE2L6, UPP1, USP18, VAMP5, VAMP8, VCAM1, WARS1, XAF1, XCL1, ZBP1, ZNFX1 |
| KRAS_SIGNALING_DN | ABCB11, ABCG4, ACTC1, ADRA2C, AKR1B10, ALOX12B, AMBN, ARHGDIG, ARPP21, ASB7, ATP4A, ATP6V1B1, BARD1, BMPR1B, BRDT, BTG2, C5, CACNA1F, CACNG1, CALCB, CALML5, CAMK1D, CAPN9, CCDC106, CCNA1, CCR8, CD207, CD40LG, CD80, CDH16, CDKAL1, CELSR2, CHRNG, CHST2, CKM, CLDN16, CLDN8, CLPS, CLSTN3, CNTFR, COL2A1, COPZ2, COQ8A, CPA2, CPB1, CPEB3, CYP11B2, CYP39A1, DCC, DLK2, DTNB, EDAR, EDN1, EDN2, EFHD1, EGF, ENTPD7, EPHA5, FGF16, FGF22, FGFR3, FGGY, FSHB, GAMT, GDNF, GP1BA, GP2, GPR19, GPR3, GPRC5C, GRID2, GTF3C5, HNF1A, HSD11B2, HTR1B, HTR1D, IDUA, IFI44L, IFNG, IGFBP2, IL12B, IL5, INSL5, IRS4, ITGB1BP2, ITIH3, KCND1, KCNE2, KCNMB1, KCNN1, KCNQ2, KLHDC8A, KLK7, KLK8, KMT2D, KRT1, KRT13, KRT15, KRT4, KRT5, LFNG, LGALS7, LYPD3, MACROH2A2, MAGIX, MAST3, MEFV, MFSD6, MSH5, MTHFR, MX1, MYH7, MYO15A, MYOT, NGB, NOS1, NPHS1, NPY4R, NR4A2, NR6A1, NRIP2, NTF3, NUDT11, OXT, P2RX6, P2RY4, PAX3, PAX4, PCDHB1, PDCD1, PDE6B, PDK2, PKP1, PLAG1, PNMT, PRKN, PRODH, PROP1, PTGFR, PTPRJ, RGS11, RIBC2, RSAD2, RYR1, RYR2, SCGB1A1, SCN10A, SELENOP, SERPINA10, SERPINB2, SGK1, SHOX2, SIDT1, SKIL, SLC12A3, SLC16A7, SLC25A23, SLC29A3, SLC30A3, SLC38A3, SLC5A5, SLC6A14, SLC6A3, SMPX, SNCB, SNN, SOX10, SPHK2, SPRR3, SPTBN2, SSTR4, STAG3, SYNPO, TAS2R4, TCF7L1, TCL1A, TENM2, TENT5C, TEX15, TFAP2B, TFCP2L1, TFF2, TG, TGFB2, TGM1, THNSL2, THRB, TLX1, TNNI3, TSHB, UGT2B17, UPK3B, VPREB1, VPS50, WNT16, YBX2, YPEL1, ZBTB16, ZC2HC1C, ZNF112 |
| KRAS_SIGNALING_UP | ABCB1, ACE, ADAM17, ADAM8, ADAMDEC1, ADGRA2, ADGRL4, AKAP12, AKT2, ALDH1A2, ALDH1A3, AMMECR1, ANGPTL4, ANKH, ANO1, ANXA10, APOD, ARG1, ATG10, AVL9, BIRC3, BMP2, BPGM, BTBD3, BTC, C3AR1, CA2, CAB39L, CBL, CBR4, CBX8, CCL20, CCND2, CCSER2, CD37, CDADC1, CFB, CFH, CFHR2, CIDEA, CLEC4A, CMKLR1, CPE, CROT, CSF2, CSF2RA, CTSS, CXCL10, CXCR4, DCBLD2, DNMBP, DOCK2, DUSP6, EMP1, ENG, EPB41L3, EPHB2, EREG, ERO1A, ETS1, ETV1, ETV4, ETV5, EVI5, F13A1, F2RL1, FBXO4, FCER1G, FGF9, FLT4, FUCA1, G0S2, GABRA3, GADD45G, GALNT3, GFPT2, GLRX, GNG11, GPNMB, GPRC5B, GUCY1A1, GYPC, H2BC3, HBEGF, HDAC9, HKDC1, HOXD11, HSD11B1, ID2, IGF2, IGFBP3, IKZF1, IL10RA, IL1B, IL1RL2, IL2RG, IL33, IL7R, INHBA, IRF8, ITGA2, ITGB2, ITGBL1, JUP, KCNN4, KIF5C, KLF4, LAPTM5, LAT2, LCP1, LIF, LY96, MAFB, MALL, MAP3K1, MAP4K1, MAP7, MMD, MMP10, MMP11, MMP9, MPZL2, MTMR10, MYCN, NAP1L2, NGF, NIN, NR0B2, NR1H4, NRP1, PCP4, PCSK1N, PDCD1LG2, PECAM1, PEG3, PIGR, PLAT, PLAU, PLAUR, PLEK2, PLVAP, PPBP, PPP1R15A, PRDM1, PRELID3B, PRKG2, PRRX1, PSMB8, PTBP2, PTCD2, PTGS2, PTPRR, RABGAP1L, RBM4, RBP4, RELN, RETN, RGS16, SATB1, SCG3, SCG5, SCN1B, SDCCAG8, SEMA3B, SERPINA3, SLPI, SNAP25, SNAP91, SOX9, SPARCL1, SPON1, SPP1, SPRY2, ST6GAL1, STRN, TFPI, TLR8, TMEM100, TMEM158, TMEM176A, TMEM176B, TNFAIP3, TNFRSF1B, TNNT2, TOR1AIP2, TPH1, TRAF1, TRIB1, TRIB2, TSPAN1, TSPAN13, TSPAN7, USH1C, USP12, VWA5A, WDR33, WNT7A, YRDC, ZNF277, ZNF639 |
| MITOTIC_SPINDLE | ABI1, ABL1, ABR, ACTN4, AKAP13, ALMS1, ALS2, ANLN, APC, ARAP3, ARF6, ARFGEF1, ARFIP2, ARHGAP10, ARHGAP27, ARHGAP29, ARHGAP4, ARHGAP5, ARHGDIA, ARHGEF11, ARHGEF12, ARHGEF2, ARHGEF3, ARHGEF7, ARL8A, ATG4B, AURKA, BCAR1, BCL2L11, BCR, BIN1, BIRC5, BRCA2, BUB1, CAPZB, CCDC88A, CCNB2, CD2AP, CDC27, CDC42, CDC42BPA, CDC42EP1, CDC42EP2, CDC42EP4, CDK1, CDK5RAP2, CENPE, CENPF, CENPJ, CEP131, CEP192, CEP250, CEP57, CEP72, CKAP5, CLASP1, CLIP1, CLIP2, CNTRL, CNTROB, CSNK1D, CTTN, CYTH2, DLG1, DLGAP5, DOCK2, DOCK4, DST, DYNC1H1, DYNLL2, ECT2, EPB41, EPB41L2, ESPL1, EZR, FARP1, FBXO5, FGD4, FGD6, FLNA, FLNB, FSCN1, GEMIN4, GSN, HDAC6, HOOK3, INCENP, ITSN1, KATNA1, KATNB1, KIF11, KIF15, KIF1B, KIF20B, KIF22, KIF23, KIF2C, KIF3B, KIF3C, KIF4A, KIF5B, KIFAP3, KLC1, KNTC1, KPTN, LATS1, LLGL1, LMNB1, LRPPRC, MAP1S, MAP3K11, MAPRE1, MARCKS, MARK4, MID1, MID1IP1, MYH10, MYH9, MYO1E, MYO9B, NCK1, NCK2, NDC80, NEDD9, NEK2, NET1, NF1, NIN, NOTCH2, NUMA1, NUSAP1, OPHN1, PAFAH1B1, PALLD, PCGF5, PCM1, PCNT, PDLIM5, PIF1, PKD2, PLEKHG2, PLK1, PPP4R2, PRC1, PREX1, PXN, RAB3GAP1, RABGAP1, RACGAP1, RALBP1, RANBP9, RAPGEF5, RAPGEF6, RASA1, RASA2, RASAL2, RFC1, RHOF, RHOT2, RICTOR, ROCK1, SAC3D1, SASS6, SEPTIN9, SHROOM1, SHROOM2, SMC1A, SMC3, SMC4, SORBS2, SOS1, SPTAN1, SPTBN1, SSH2, STAU1, STK38L, SUN2, SYNPO, TAOK2, TBCD, TIAM1, TLK1, TOP2A, TPX2, TRIO, TSC1, TTK, TUBA4A, TUBD1, TUBGCP2, TUBGCP3, TUBGCP5, TUBGCP6, UXT, VCL, WASF1, WASF2, WASL, YWHAE |
| MTORC1_SIGNALING | ABCF2, ACACA, ACLY, ACSL3, ACTR2, ACTR3, ADD3, ADIPOR2, AK4, ALDOA, ARPC5L, ASNS, ATP2A2, ATP5MC1, ATP6V1D, AURKA, BCAT1, BHLHE40, BTG2, BUB1, CACYBP, CALR, CANX, CCNF, CCNG1, CCT6A, CD9, CDC25A, CDKN1A, CFP, COPS5, CORO1A, CTH, CTSC, CXCR4, CYB5B, CYP51A1, DAPP1, DDIT3, DDIT4, DDX39A, DHCR24, DHCR7, DHFR, EBP, EDEM1, EEF1E1, EGLN3, EIF2S2, ELOVL5, ELOVL6, ENO1, EPRS1, ERO1A, ETF1, FADS1, FADS2, FDXR, FGL2, FKBP2, G6PD, GAPDH, GBE1, GCLC, GGA2, GLA, GLRX, GMPS, GOT1, GPI, GSK3B, GSR, GTF2H1, HK2, HMBS, HMGCR, HMGCS1, HPRT1, HSP90B1, HSPA4, HSPA5, HSPA9, HSPD1, HSPE1, IDH1, IDI1, IFI30, IFRD1, IGFBP5, IMMT, INSIG1, ITGB2, LDHA, LDLR, LGMN, LTA4H, M6PR, MAP2K3, MCM2, MCM4, ME1, MLLT11, MTHFD2, MTHFD2L, NAMPT, NFIL3, NFKBIB, NFYC, NHERF1, NIBAN1, NMT1, NUFIP1, NUP205, NUPR1, P4HA1, PDAP1, PDK1, PFKL, PGK1, PGM1, PHGDH, PIK3R3, PITPNB, PLK1, PLOD2, PNO1, PNP, POLR3G, PPA1, PPIA, PPP1R15A, PRDX1, PSAT1, PSMA3, PSMA4, PSMB5, PSMC2, PSMC4, PSMC6, PSMD12, PSMD13, PSMD14, PSME3, PSMG1, PSPH, QDPR, RAB1A, RDH11, RIT1, RPA1, RPN1, RRM2, RRP9, SC5D, SCD, SDF2L1, SEC11A, SERP1, SERPINH1, SHMT2, SKAP2, SLA, SLC1A4, SLC1A5, SLC2A1, SLC2A3, SLC37A4, SLC6A6, SLC7A11, SLC7A5, SORD, SQLE, SQSTM1, SRD5A1, SSR1, STARD4, STC1, STIP1, SYTL2, TBK1, TCEA1, TES, TFRC, TM7SF2, TMEM97, TOMM40, TPI1, TRIB3, TUBA4A, TUBG1, TXNRD1, UBE2D3, UCHL5, UFM1, UNG, USO1, VLDLR, WARS1, XBP1, YKT6 |
| MYC_TARGETS_V1 | ABCE1, ACP1, AIMP2, AP3S1, APEX1, BUB3, C1QBP, CAD, CANX, CBX3, CCNA2, CCT2, CCT3, CCT4, CCT5, CCT7, CDC20, CDC45, CDK2, CDK4, CLNS1A, CNBP, COPS5, COX5A, CSTF2, CTPS1, CUL1, CYC1, DDX18, DDX21, DEK, DHX15, DUT, EEF1B2, EIF1AX, EIF2S1, EIF2S2, EIF3B, EIF3D, EIF3J, EIF4A1, EIF4E, EIF4G2, EIF4H, EPRS1, ERH, ETF1, EXOSC7, FAM120A, FBL, G3BP1, GLO1, GNL3, GOT2, GSPT1, H2AZ1, HDAC2, HDDC2, HDGF, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPD, HNRNPR, HNRNPU, HPRT1, HSP90AB1, HSPD1, HSPE1, IARS1, IFRD1, ILF2, IMPDH2, KARS1, KPNA2, KPNB1, LDHA, LSM2, LSM7, MAD2L1, MCM2, MCM4, MCM5, MCM6, MCM7, MRPL23, MRPL9, MRPS18B, MYC, NAP1L1, NCBP1, NCBP2, NDUFAB1, NHP2, NME1, NOLC1, NOP16, NOP56, NPM1, ODC1, ORC2, PA2G4, PABPC1, PABPC4, PCBP1, PCNA, PGK1, PHB1, PHB2, POLD2, POLE3, PPIA, PPM1G, PRDX3, PRDX4, PRPF31, PRPS2, PSMA1, PSMA2, PSMA4, PSMA6, PSMA7, PSMB2, PSMB3, PSMC4, PSMC6, PSMD1, PSMD14, PSMD3, PSMD7, PSMD8, PTGES3, PWP1, RACK1, RAD23B, RAN, RANBP1, RFC4, RNPS1, RPL14, RPL18, RPL22, RPL34, RPL6, RPLP0, RPS10, RPS2, RPS3, RPS5, RPS6, RRM1, RRP9, RSL1D1, RUVBL2, SERBP1, SET, SF3A1, SF3B3, SLC25A3, SMARCC1, SNRPA, SNRPA1, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPG, SRM, SRPK1, SRSF1, SRSF2, SRSF3, SRSF7, SSB, SSBP1, STARD7, SYNCRIP, TARDBP, TCP1, TFDP1, TOMM70, TRA2B, TRIM28, TUFM, TXNL4A, TYMS, U2AF1, UBA2, UBE2E1, UBE2L3, USP1, VBP1, VDAC1, VDAC3, XPO1, XPOT, XRCC6, YWHAE, YWHAQ |
| MYC_TARGETS_V2 | AIMP2, BYSL, CBX3, CDK4, DCTPP1, DDX18, DUSP2, EXOSC5, FARSA, GNL3, GRWD1, HK2, HSPD1, HSPE1, IMP4, IPO4, LAS1L, MAP3K6, MCM4, MCM5, MPHOSPH10, MRTO4, MYBBP1A, MYC, NDUFAF4, NIP7, NOC4L, NOLC1, NOP16, NOP2, NOP56, NPM1, PA2G4, PES1, PHB1, PLK1, PLK4, PPAN, PPRC1, PRMT3, PUS1, RABEPK, RCL1, RRP12, RRP9, SLC19A1, SLC29A2, SORD, SRM, SUPV3L1, TBRG4, TCOF1, TFB2M, TMEM97, UNG, UTP20, WDR43, WDR74 |
| MYOGENESIS | ABLIM1, ACHE, ACSL1, ACTA1, ACTC1, ACTN2, ACTN3, ADAM12, ADCY9, AEBP1, AGL, AGRN, AK1, AKT2, ANKRD2, APLNR, APOD, APP, ATP2A1, ATP6AP1, BAG1, BDKRB2, BHLHE40, BIN1, CACNA1H, CACNG1, CAMK2B, CASQ1, CASQ2, CAV3, CD36, CDH13, CDKN1A, CFD, CHRNA1, CHRNB1, CHRNG, CKB, CKM, CKMT2, CLU, CNN3, COL15A1, COL1A1, COL3A1, COL4A2, COL6A2, COL6A3, COX6A2, COX7A1, CRAT, CRYAB, CSRP3, CTF1, DAPK2, DENND2B, DES, DMD, DMPK, DTNA, EFS, EIF4A2, ENO3, EPHB3, ERBB3, FABP3, FDPS, FGF2, FHL1, FKBP1B, FLII, FOXO4, FST, FXYD1, GAA, GABARAPL2, GADD45B, GJA5, GNAO1, GPX3, GSN, HBEGF, HDAC5, HRC, HSPB2, HSPB8, IFRD1, IGF1, IGFBP3, IGFBP7, ITGA7, ITGB1, ITGB4, ITGB5, KCNH1, KCNH2, KIFC3, KLF5, LAMA2, LARGE1, LDB3, LPIN1, LSP1, MAPK12, MAPRE3, MB, MEF2A, MEF2C, MEF2D, MRAS, MYBPC3, MYBPH, MYF6, MYH1, MYH11, MYH2, MYH3, MYH4, MYH7, MYH8, MYH9, MYL1, MYL11, MYL2, MYL3, MYL4, MYL6B, MYL7, MYLK, MYO1C, MYOG, MYOM1, MYOM2, MYOZ1, NAV2, NCAM1, NOS1, NOTCH1, NQO1, OCEL1, PC, PDE4DIP, PDLIM7, PFKM, PGAM2, PICK1, PKIA, PLXNB2, PPFIA4, PPP1R3C, PRNP, PSEN2, PTGIS, PTP4A3, PVALB, PYGM, RB1, REEP1, RIT1, RYR1, SCD, SCHIP1, SGCA, SGCD, SGCG, SH2B1, SH3BGR, SIRT2, SLC6A8, SLN, SMTN, SOD3, SORBS1, SORBS3, SPARC, SPDEF, SPEG, SPHK1, SPTAN1, SSPN, STC2, SVIL, SYNGR2, TAGLN, TCAP, TEAD4, TGFB1, TNNC1, TNNC2, TNNI1, TNNI2, TNNT1, TNNT2, TNNT3, TPD52L1, TPM2, TPM3, TSC2, VIPR1, WWTR1 |
| NOTCH_SIGNALING | APH1A, ARRB1, CCND1, CUL1, DLL1, DTX1, DTX2, DTX4, FBXW11, FZD1, FZD5, FZD7, HES1, HEYL, JAG1, KAT2A, LFNG, MAML2, NOTCH1, NOTCH2, NOTCH3, PPARD, PRKCA, PSEN2, PSENEN, RBX1, SAP30, SKP1, ST3GAL6, TCF7L2, WNT2, WNT5A |
| OXIDATIVE_PHOSPHORYLATION | ABCB7, ACAA1, ACAA2, ACADM, ACADSB, ACADVL, ACAT1, ACO2, AFG3L2, AIFM1, ALAS1, ALDH6A1, ATP1B1, ATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP5MC1, ATP5MC2, ATP5MC3, ATP5ME, ATP5MF, ATP5MG, ATP5PB, ATP5PD, ATP5PF, ATP5PO, ATP6AP1, ATP6V0B, ATP6V0C, ATP6V0E1, ATP6V1C1, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1H, BAX, BCKDHA, BDH2, CASP7, COX10, COX11, COX15, COX17, COX4I1, COX5A, COX5B, COX6A1, COX6B1, COX6C, COX7A2, COX7A2L, COX7B, COX7C, COX8A, CPT1A, CS, CYB5A, CYB5R3, CYC1, CYCS, DECR1, DLAT, DLD, DLST, ECH1, ECHS1, ECI1, ETFA, ETFB, ETFDH, FDX1, FH, FXN, GLUD1, GOT2, GPI, GPX4, GRPEL1, HADHA, HADHB, HCCS, HSD17B10, HSPA9, HTRA2, IDH1, IDH2, IDH3A, IDH3B, IDH3G, IMMT, ISCA1, ISCU, LDHA, LDHB, LRPPRC, MAOB, MDH1, MDH2, MFN2, MGST3, MPC1, MRPL11, MRPL15, MRPL34, MRPL35, MRPS11, MRPS12, MRPS15, MRPS22, MRPS30, MTRF1, MTRR, MTX2, NDUFA1, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NNT, NQO2, OAT, OGDH, OPA1, OXA1L, PDHA1, PDHB, PDHX, PDK4, PDP1, PHB2, PHYH, PMPCA, POLR2F, POR, PRDX3, RETSAT, RHOT1, RHOT2, SDHA, SDHB, SDHC, SDHD, SLC25A11, SLC25A12, SLC25A20, SLC25A3, SLC25A4, SLC25A5, SLC25A6, SUCLA2, SUCLG1, SUPV3L1, SURF1, TCIRG1, TIMM10, TIMM13, TIMM17A, TIMM50, TIMM8B, TIMM9, TOMM22, TOMM70, UQCR10, UQCR11, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ, VDAC1, VDAC2, VDAC3 |
| P53_PATHWAY | ABAT, ABCC5, ABHD4, ACVR1B, ADA, AEN, AK1, ALOX15B, ANKRA2, APAF1, APP, ATF3, BAIAP2, BAK1, BAX, BLCAP, BMP2, BTG1, BTG2, CASP1, CCND2, CCND3, CCNG1, CCNK, CCP110, CD81, CD82, CDH13, CDK5R1, CDKN1A, CDKN2A, CDKN2AIP, CDKN2B, CEBPA, CGRRF1, CLCA2, COQ8A, CSRNP2, CTSD, CTSF, CYFIP2, DCXR, DDB2, DDIT3, DDIT4, DEF6, DGKA, DNTTIP2, DRAM1, EI24, ELP1, EPHA2, EPHX1, EPS8L2, ERCC5, F2R, FAM162A, FAS, FBXW7, FDXR, FGF13, FOS, FOXO3, FUCA1, GADD45A, GLS2, GM2A, GPX2, H1-2, H2AC25, H2AJ, HBEGF, HDAC3, HEXIM1, HINT1, HMOX1, HRAS, HSPA4L, IER3, IER5, IFI30, IL1A, INHBB, IP6K2, IRAG2, IRAK1, ISCU, ITGB4, JAG2, JUN, KIF13B, KLF4, KLK8, KRT17, LDHB, LIF, MAPKAPK3, MDM2, MKNK2, MXD1, MXD4, NDRG1, NHLH2, NINJ1, NOL8, NOTCH1, NUDT15, NUPR1, OSGIN1, PCNA, PDGFA, PERP, PHLDA3, PIDD1, PITPNC1, PLK2, PLK3, PLXNB2, PMM1, POLH, POM121, PPM1D, PPP1R15A, PRKAB1, PRMT2, PROCR, PTPN14, PTPRE, PVT1, RAB40C, RACK1, RAD51C, RAD9A, RALGDS, RAP2B, RB1, RCHY1, RETSAT, RGS16, RHBDF2, RNF19B, RPL18, RPL36, RPS12, RPS27L, RRAD, RRP8, RXRA, S100A10, S100A4, SAT1, SDC1, SEC61A1, SERPINB5, SERTAD3, SESN1, SFN, SLC19A2, SLC35D1, SLC3A2, SLC7A11, SOCS1, SP1, SPHK1, ST14, STEAP3, STOM, TAP1, TAX1BP3, TCHH, TCN2, TGFA, TGFB1, TM4SF1, TM7SF3, TNFSF9, TNNI1, TOB1, TP53, TP63, TPD52L1, TPRKB, TRAF4, TRAFD1, TRIAP1, TRIB3, TSC22D1, TSPYL2, TXNIP, UPP1, VAMP8, VDR, VWA5A, WRAP73, WWP1, XPC, ZBTB16, ZFP36L1, ZMAT3, ZNF365 |
| PANCREAS_BETA_CELLS | ABCC8, AKT3, CHGA, DCX, DPP4, ELP4, FOXA2, FOXO1, G6PC2, GCG, GCK, HNF1A, IAPP, INS, INSM1, ISL1, LMO2, MAFB, NEUROD1, NEUROG3, NKX2-2, NKX6-1, PAK3, PAX4, PAX6, PCSK1, PCSK2, PDX1, PKLR, SCGN, SEC11A, SLC2A2, SPCS1, SRP14, SRP9, SRPRB, SST, STXBP1, SYT13, VDR |
| PEROXISOME | ABCB1, ABCB4, ABCB9, ABCC5, ABCC8, ABCD1, ABCD2, ABCD3, ACAA1, ACOT8, ACOX1, ACSL1, ACSL4, ACSL5, ALB, ALDH1A1, ALDH9A1, ATXN1, BCL10, CACNA1B, CADM1, CAT, CDK7, CEL, CLN6, CLN8, CNBP, CRABP1, CRABP2, CRAT, CTBP1, CTPS1, DHCR24, DHRS3, DIO1, DLG4, ECH1, ECI2, EHHADH, ELOVL5, EPHX2, ERCC1, ERCC3, ESR2, FABP6, FADS1, FDPS, FIS1, GNPAT, GSTK1, HAO2, HMGCL, HRAS, HSD11B2, HSD17B11, HSD17B4, HSD3B7, IDE, IDH1, IDH2, IDI1, ISOC1, ITGB1BP1, LONP2, MLYCD, MSH2, MVP, NR1I2, NUDT19, PABPC1, PEX11A, PEX11B, PEX13, PEX14, PEX2, PEX5, PEX6, PRDX1, PRDX5, RDH11, RETSAT, RXRG, SCGB1A1, SCP2, SEMA3C, SERPINA6, SIAH1, SLC23A2, SLC25A17, SLC25A19, SLC25A4, SLC27A2, SLC35B2, SMARCC1, SOD1, SOD2, STS, SULT2B1, TOP2A, TSPO, TTR, UGT2B17, VPS4B, YWHAH |
| PI3K_AKT_MTOR_SIGNALING | ACACA, ACTR2, ACTR3, ADCY2, AKT1, AKT1S1, AP2M1, ARF1, ARHGDIA, ARPC3, ATF1, CAB39, CAB39L, CALR, CAMK4, CDK1, CDK2, CDK4, CDKN1A, CDKN1B, CFL1, CLTC, CSNK2B, CXCR4, DAPP1, DDIT3, DUSP3, E2F1, ECSIT, EGFR, EIF4E, FASLG, FGF17, FGF22, FGF6, GNA14, GNGT1, GRB2, GRK2, GSK3B, HRAS, HSP90B1, IL2RG, IL4, IRAK4, ITPR2, LCK, MAP2K3, MAP2K6, MAP3K7, MAPK1, MAPK10, MAPK8, MAPK9, MAPKAP1, MKNK1, MKNK2, MYD88, NCK1, NFKBIB, NGF, NOD1, PAK4, PDK1, PFN1, PIK3R3, PIKFYVE, PIN1, PITX2, PLA2G12A, PLCB1, PLCG1, PPP1CA, PPP2R1B, PRKAA2, PRKAG1, PRKAR2A, PRKCB, PTEN, PTPN11, RAC1, RAF1, RALB, RIPK1, RIT1, RPS6KA1, RPS6KA3, RPTOR, SFN, SLA, SLC2A1, SMAD2, SQSTM1, STAT2, TBK1, THEM4, TIAM1, TNFRSF1A, TRAF2, TRIB3, TSC2, UBE2D3, UBE2N, VAV3, YWHAB |
| PROTEIN_SECRETION | ABCA1, ADAM10, ANP32E, AP1G1, AP2B1, AP2M1, AP2S1, AP3B1, AP3S1, ARCN1, ARF1, ARFGAP3, ARFGEF1, ARFGEF2, ARFIP1, ATP1A1, ATP6V1B1, ATP6V1H, ATP7A, BET1, BNIP3, CAV2, CD63, CLCN3, CLN5, CLTA, CLTC, COG2, COPB1, COPB2, COPE, CTSC, DNM1L, DOP1A, DST, EGFR, ERGIC3, GALC, GBF1, GLA, GNAS, GOLGA4, GOSR2, ICA1, IGF2R, KIF1B, KRT18, LAMP2, LMAN1, M6PR, MAPK1, MON2, NAPA, NAPG, OCRL, PAM, PPT1, RAB14, RAB22A, RAB2A, RAB5A, RAB9A, RER1, RPS6KA3, SCAMP1, SCAMP3, SCRN1, SEC22B, SEC24D, SEC31A, SGMS1, SH3GL2, SNAP23, SNX2, SOD1, SSPN, STAM, STX12, STX16, STX7, TMED10, TMED2, TMX1, TOM1L1, TPD52, TSG101, TSPAN8, USO1, VAMP3, VAMP4, VAMP7, VPS45, VPS4B, YIPF6, YKT6, ZW10 |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | ABCC1, ATOX1, CAT, CDKN2D, EGLN2, ERCC2, FES, FTL, G6PD, GCLC, GCLM, GLRX, GLRX2, GPX3, GPX4, GSR, HHEX, HMOX2, IPCEF1, JUNB, LAMTOR5, LSP1, MBP, MGST1, MPO, MSRA, NDUFA6, NDUFB4, NDUFS2, NQO1, OXSR1, PDLIM1, PFKP, PRDX1, PRDX2, PRDX4, PRDX6, PRNP, PTPA, SBNO2, SCAF4, SELENOS, SOD1, SOD2, SRXN1, STK25, TXN, TXNRD1, TXNRD2 |
| SPERMATOGENESIS | ACE, ACRBP, ACRV1, ACTL7B, ADAD1, ADAM2, ADCYAP1, AGFG1, AKAP4, ALOX15, ARL4A, ART3, AURKA, BRAF, BUB1, CAMK4, CCNA1, CCNB2, CCT6B, CDK1, CDKN3, CFTR, CHFR, CHRM4, CLGN, CLPB, CLVS1, CNIH2, COIL, CRISP2, CSNK2A2, CST8, DBF4, DCC, DDX25, DDX4, DMC1, DMRT1, DNAJB8, DPEP3, ELOVL3, EZH2, GAD1, GAPDHS, GFI1, GMCL1, GPR182, GRM8, GSG1, GSTM3, H1-6, HBZ, HOXB1, HSPA1L, HSPA2, HSPA4L, HTR5A, IDE, IFT88, IL12RB2, IL13RA2, IP6K1, JAM3, KIF2C, LDHC, LPIN1, MAP7, MAST2, MEP1B, MLF1, MLLT10, MTNR1A, MTOR, NAA11, NCAPH, NEFH, NEK2, NF2, NOS1, NPHP1, NPY5R, OAZ3, ODF1, PACRG, PAPOLB, PARP2, PCSK1N, PCSK4, PDHA2, PEBP1, PGK2, PGS1, PHF7, PHKG2, PIAS2, POMC, PRKAR2A, PRM2, PSMG1, RAD17, RFC4, RPL39L, SCG3, SCG5, SEPTIN4, SHE, SIRT1, SLC12A2, SLC2A5, SNAP91, SPATA6, STAM2, STRBP, SYCP1, TALDO1, TCP11, TEKT2, THEG, TKTL1, TLE4, TNNI3, TNP1, TNP2, TOPBP1, TSN, TSSK2, TTK, TUBA3C, TULP2, VDAC3, YBX2, ZC2HC1C, ZC3H14, ZNRF4, ZPBP |
| TGF_BETA_SIGNALING | ACVR1, APC, ARID4B, BCAR3, BMP2, BMPR1A, BMPR2, CDH1, CDK9, CDKN1C, CTNNB1, ENG, FKBP1A, FNTA, FURIN, HDAC1, HIPK2, ID1, ID2, ID3, IFNGR2, JUNB, KLF10, LEFTY2, LTBP2, MAP3K7, NCOR2, NOG, PMEPA1, PPM1A, PPP1CA, PPP1R15A, RAB31, RHOA, SERPINE1, SKI, SKIL, SLC20A1, SMAD1, SMAD3, SMAD6, SMAD7, SMURF1, SMURF2, SPTBN1, TGFB1, TGFBR1, TGIF1, THBS1, TJP1, TRIM33, UBE2D3, WWTR1, XIAP |
| TNFA_SIGNALING_VIA_NFKB | ABCA1, ACKR3, AREG, ATF3, ATP2B1, B4GALT1, B4GALT5, BCL2A1, BCL3, BCL6, BHLHE40, BIRC2, BIRC3, BMP2, BTG1, BTG2, BTG3, CCL2, CCL20, CCL4, CCL5, CCN1, CCND1, CCNL1, CCRL2, CD44, CD69, CD80, CD83, CDKN1A, CEBPB, CEBPD, CFLAR, CLCF1, CSF1, CSF2, CXCL1, CXCL10, CXCL11, CXCL2, CXCL3, CXCL6, DENND5A, DNAJB4, DRAM1, DUSP1, DUSP2, DUSP4, DUSP5, EDN1, EFNA1, EGR1, EGR2, EGR3, EHD1, EIF1, ETS2, F2RL1, F3, FJX1, FOS, FOSB, FOSL1, FOSL2, FUT4, G0S2, GADD45A, GADD45B, GCH1, GEM, GFPT2, GPR183, HBEGF, HES1, ICAM1, ICOSLG, ID2, IER2, IER3, IER5, IFIH1, IFIT2, IFNGR2, IL12B, IL15RA, IL18, IL1A, IL1B, IL23A, IL6, IL6ST, IL7R, INHBA, IRF1, IRS2, JAG1, JUN, JUNB, KDM6B, KLF10, KLF2, KLF4, KLF6, KLF9, KYNU, LAMB3, LDLR, LIF, LITAF, MAFF, MAP2K3, MAP3K8, MARCKS, MCL1, MSC, MXD1, MYC, NAMPT, NFAT5, NFE2L2, NFIL3, NFKB1, NFKB2, NFKBIA, NFKBIE, NINJ1, NR4A1, NR4A2, NR4A3, OLR1, PANX1, PDE4B, PDLIM5, PER1, PFKFB3, PHLDA1, PHLDA2, PLAU, PLAUR, PLEK, PLK2, PLPP3, PMEPA1, PNRC1, PPP1R15A, PTGER4, PTGS2, PTPRE, PTX3, RCAN1, REL, RELA, RELB, RHOB, RIGI, RIPK2, RNF19B, SAT1, SDC4, SERPINB2, SERPINB8, SERPINE1, SGK1, SIK1, SLC16A6, SLC2A3, SLC2A6, SMAD3, SNN, SOCS3, SOD2, SPHK1, SPSB1, SQSTM1, STAT5A, TANK, TAP1, TGIF1, TIPARP, TLR2, TNC, TNF, TNFAIP2, TNFAIP3, TNFAIP6, TNFAIP8, TNFRSF9, TNFSF9, TNIP1, TNIP2, TRAF1, TRIB1, TRIP10, TSC22D1, TUBB2A, VEGFA, YRDC, ZBTB10, ZC3H12A, ZFP36 |
| UNFOLDED_PROTEIN_RESPONSE | ALDH18A1, ARFGAP1, ASNS, ATF3, ATF4, ATF6, ATP6V0D1, BAG3, BANF1, CALR, CCL2, CEBPB, CEBPG, CHAC1, CKS1B, CNOT2, CNOT4, CNOT6, CXXC1, DCP1A, DCP2, DCTN1, DDIT4, DDX10, DKC1, DNAJA4, DNAJB9, DNAJC3, EDC4, EDEM1, EEF2, EIF2AK3, EIF2S1, EIF4A1, EIF4A2, EIF4A3, EIF4E, EIF4EBP1, EIF4G1, ERN1, ERO1A, EXOC2, EXOSC1, EXOSC10, EXOSC2, EXOSC4, EXOSC5, EXOSC9, FKBP14, FUS, GEMIN4, GOSR2, H2AX, HERPUD1, HSP90B1, HSPA5, HSPA9, HYOU1, IARS1, IFIT1, IGFBP1, IMP3, KDELR3, KHSRP, KIF5B, LSM1, LSM4, MTHFD2, MTREX, NABP1, NFYA, NFYB, NHP2, NOLC1, NOP14, NOP56, NPM1, PAIP1, PARN, PDIA5, PDIA6, POP4, PREB, PSAT1, RPS14, RRP9, SDAD1, SEC11A, SEC31A, SERP1, SHC1, SKIC3, SLC1A4, SLC30A5, SLC7A5, SPCS1, SPCS3, SRPRA, SRPRB, SSR1, STC2, TARS1, TATDN2, TSPYL2, TUBB2A, VEGFA, WFS1, WIPI1, XBP1, XPOT, YIF1A, YWHAZ, ZBTB17 |
| UV_RESPONSE_DN | ABCC1, ACVR2A, ADD3, ADGRL2, ADORA2B, AGGF1, AKT3, AMPH, ANXA2, ANXA4, APBB2, ARHGEF9, ATP2B1, ATP2B4, ATP2C1, ATRN, ATRX, ATXN1, BCKDHB, BDNF, BHLHE40, BMPR1A, CACNA1A, CAP2, CAV1, CCN1, CDC42BPA, CDK13, CDKN1B, CDON, CELF2, CITED2, COL11A1, COL1A1, COL1A2, COL3A1, COL5A2, DAB2, DBP, DDAH1, DLC1, DLG1, DMAC2L, DUSP1, DYRK1A, EFEMP1, ERBB2, F3, FBLN5, FHL2, FYN, FZD2, GCNT1, GJA1, GRK5, HAS2, ICA1, ID1, IGF1R, IGFBP5, INPP4B, INSIG1, IRS1, ITGB3, KALRN, KCNMA1, KIT, LAMC1, LDLR, LPAR1, LTBP1, MAGI2, MAP1B, MAP2K5, MAPK14, MET, MGLL, MGMT, MIOS, MMP16, MRPS31, MT1E, MTA1, MYC, NEK7, NFIB, NFKB1, NIPBL, NOTCH2, NR1D2, NR3C1, NRP1, PDGFRB, PDLIM5, PEX14, PHF3, PIAS3, PIK3CD, PIK3R3, PLCB4, PLPP3, PMP22, PPARG, PRDM2, PRKAR2B, PRKCA, PRKCE, PTEN, PTGFR, PTPN21, PTPRM, RASA2, RBPMS, RGS4, RND3, RUNX1, RXRA, SCAF8, SCHIP1, SCN8A, SDC2, SERPINE1, SFMBT1, SIPA1L1, SLC22A18, SLC7A1, SMAD3, SMAD7, SNAI2, SPOP, SRI, SYNE1, SYNJ2, TENT4A, TFPI, TGFBR2, TGFBR3, TJP1, TOGARAM1, VAV2, VLDLR, WDR37, YTHDC1, ZMIZ1 |
| UV_RESPONSE_UP | ABCB1, ACAA1, AGO2, ALAS1, ALDOA, AMD1, AP2S1, APOM, AQP3, ARRB2, ASNS, ATF3, ATP6V1C1, ATP6V1F, BAK1, BCL2L11, BID, BMP2, BSG, BTG1, BTG2, BTG3, C4BPB, CA2, CASP3, CCK, CCND3, CCNE1, CDC34, CDC5L, CDK2, CDKN1C, CDKN2B, CDO1, CEBPG, CHKA, CHRNA5, CLCN2, CLTB, CNP, COL2A1, CREG1, CTSV, CXCL2, CYB5B, CYB5R1, CYP1A1, DDX21, DGAT1, DLG4, DNAJA1, DNAJB1, E2F5, EIF2S3, EIF5, ENO2, EPCAM, EPHX1, FEN1, FGF18, FKBP4, FMO1, FOS, FOSB, FURIN, GAL, GCH1, GGH, GLS, GPX3, GRINA, GRPEL1, H2AX, HLA-F, HMOX1, HNRNPU, HSPA13, HSPA2, HTR7, HYAL2, ICAM1, IGFBP2, IL6, IL6ST, IRF1, JUNB, KCNH2, KLHDC3, LHX2, LYN, MAOA, MAPK8IP2, MARK2, MGAT1, MMP14, MRPL23, MSX1, NAT1, NFKBIA, NKX2-5, NPTX2, NPTXR, NR4A1, NTRK3, NUP58, NXF1, OLFM1, ONECUT1, PARP2, PDAP1, PDLIM3, PLCL1, POLE3, POLG2, POLR2H, PPAT, PPIF, PPP1R2, PPT1, PRKACA, PRKCD, PRPF3, PSMC3, PTPRD, RAB27A, RASGRP1, RET, RFC4, RHOB, RPN1, RRAD, RXRB, SELENOW, SHOX2, SIGMAR1, SLC25A4, SLC6A12, SLC6A8, SOD2, SPR, SQSTM1, STARD3, STIP1, STK25, SULT1A1, TACR3, TAP1, TARS1, TCHH, TFRC, TGFBRAP1, TMBIM6, TST, TUBA4A, TYRO3, UROD, WIZ, YKT6 |
| WNT_BETA_CATENIN_SIGNALING | ADAM17, AXIN1, AXIN2, CCND2, CSNK1E, CTNNB1, CUL1, DKK1, DKK4, DLL1, DVL2, FRAT1, FZD1, FZD8, GNAI1, HDAC11, HDAC2, HDAC5, HEY1, HEY2, JAG1, JAG2, KAT2A, LEF1, MAML1, MYC, NCOR2, NCSTN, NKD1, NOTCH1, NOTCH4, NUMB, PPARD, PSEN2, PTCH1, RBPJ, SKP2, TCF7, TP53, WNT1, WNT5B, WNT6 |
| XENOBIOTIC_METABOLISM | ABCC2, ABCC3, ABCD2, ABHD6, ACO2, ACOX1, ACOX2, ACOX3, ACP1, ACP2, ACSM1, ADH1C, ADH5, ADH7, AHCY, AKR1C2, AKR1C3, ALAS1, ALDH2, ALDH3A1, ALDH9A1, ANGPTL3, AOX1, AP4B1, APOE, AQP9, ARG1, ARG2, ARPP19, ASL, ATOH8, ATP2A2, BCAR1, BCAT1, BLVRB, BPHL, CA2, CASP6, CAT, CBR1, CCL25, CD36, CDA, CDO1, CES1, CFB, CNDP2, COMT, CROT, CRP, CSAD, CYB5A, CYFIP2, CYP17A1, CYP1A1, CYP1A2, CYP26A1, CYP27A1, CYP2C18, CYP2E1, CYP2J2, CYP2S1, CYP4F2, DCXR, DDAH2, DDC, DDT, DHPS, DHRS1, DHRS7, ECH1, ELOVL5, ENPEP, ENTPD5, EPHA2, EPHX1, ESR1, ETFDH, ETS2, F10, F11, FABP1, FAH, FAS, FBLN1, FBP1, FETUB, FMO1, FMO3, G6PC1, GABARAPL1, GAD1, GART, GCH1, GCKR, GCLC, GCNT2, GNMT, GSR, GSS, GSTA3, GSTM4, GSTO1, GSTT2, HACL1, HES6, HGFAC, HMOX1, HNF4A, HPRT1, HRG, HSD11B1, HSD17B2, ID2, IDH1, IGF1, IGFBP1, IGFBP4, IL1R1, IRF8, ITIH1, ITIH4, JUP, KARS1, KYNU, LCAT, LEAP2, LONP1, LPIN2, MAN1A1, MAOA, MARCHF6, MBL2, MCCC2, MPP2, MT2A, MTHFD1, NDRG2, NFS1, NINJ1, NMT1, NPC1, NQO1, PAPSS2, PC, PDK4, PDLIM5, PEMT, PGD, PGRMC1, PINK1, PLG, PMM1, POR, PPARD, PROS1, PSMB10, PTGDS, PTGES, PTGES3, PTGR1, PTS, PYCR1, RAP1GAP, RBP4, REG1A, RETSAT, SAR1B, SERPINA6, SERPINE1, SERTAD1, SHMT2, SLC12A4, SLC1A5, SLC22A1, SLC35B1, SLC35D1, SLC46A3, SLC6A12, SLC6A6, SMOX, SPINT2, SSR3, TAT, TDO2, TGFB2, TKFC, TMBIM6, TMEM176B, TMEM97, TNFRSF1A, TPST1, TTPA, TYR, UGDH, UPB1, UPP1, VNN1, VTN, XDH |
Ref1